![]() The main AD symptoms include Aβ decomposition and tau hyperphosphorylation ( Madav et al., 2019 Zaplatic et al., 2019). Currently, it has been highlighted that aging is not the only cause of sporadic AD (SAD) development, while environmental and lifestyle factors including malnutrition, air pollution, oxidative stress, etc., play crucial roles in the development and progression of this disease ( Steck et al., 2018 Boccardi et al., 2019 Altuna-Azkargorta and Mendioroz-Iriarte, 2020 Cassidy et al., 2020 Jayaraj et al., 2020 Nonaka et al., 2020 Oh and Disterhoft, 2020 Wu et al., 2020). ![]() Usually, AD appears in people older than 60 years old ( Santamaría et al., 2020). ![]() AD has a prevalence of ∼45 million people around the world that may rise to ∼150 million by 2050 because of the progressive nature of the disease and limited therapeutic methods. Accordingly, the antioxidant effect of QT-SPION inhibited progression of cognitive impairment via sustaining the balance of antioxidant enzymes in the hippocampus of AD model rats.Īlzheimer’s disease (AD) appears as an outcome of neurodegeneration that is recognized with symptoms of intensive cognitive impairment ( Ramalho et al., 2020). QT-SPION also decreased the expression levels of antioxidant enzymes along with increases in expression levels of anti-apoptotic genes. This group showed similar results with the control group. The increase in expression levels of APP gene and the decrease in mir101 led to the development of AD symptoms in rats treated with AlCl 3 while these results were reversed in the AlCl 3 + QT-SPIONs group. The effect of QT-SPIONs on learning and memory deficits were closely similar to the control group. Results of behavioral tests revealed that the intensity of cognitive impairment was decelerated at both the middle and end of the treatment period. Behavioral tests and qPCR were used to evaluate the efficiency of treatments. In this study, male Wistar rats were subjected to AlCl 3, AlCl 3 + QT, AlCl 3 + SPION, and AlCl 3 + QT-SPION for 42 consecutive days. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailability. Oxidative stress in neurons is considered as a reason for development of AD. 2Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, IranĪlzheimer’s disease (AD) is a neurodegenerative disease with cognitive impairment.1Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.Elnaz Amanzadeh Jajin 1 Abolghasem Esmaeili 1* Soheila Rahgozar 1 Maryam Noorbakhshnia 2
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